Soluble salts of 4-amino-2-(4,4-dimethylimidazolidin-2-on-1-yl) pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)-amide, a process for the preparation thereof, the use thereof as pharmaceuticals and starting materials

US5795899A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus-Dieter Kampe · Bad Soden am Taunus, DE
• Ernold Granzer · Kelkheim, DE
• Michael Leineweber · Frankfurt am Main, DE
• Manfred Huttinger · Wien, DE

Key dates

• Filing date: Feb 23, 1995
• Grant date: Aug 18, 1998
• Expiry date: Feb 23, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Soluble salts of 4-amino-2-(4,4-dimethylimidazolidin-2-on-1-yl)pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)amide, a process for the preparation thereof, the use thereof as pharmaceuticals and starting materials. Salts, which are soluble and freely soluble in water, of 4-amino-2-(4,4-dimethylimidazolidin-2-on-1-yl)pyrimidine-5-carboxylic acid N-methyl-N-(3-trifluoromethylphenyl)-amide and a process for the preparation thereof are described. The compounds are suitable for the treatment of lipid metabolism disorders which are beneficially influenced by stimulation of the hepatic LDL receptor. Also described are the compounds of the formula IV ##STR1## and the salts thereof.