Library of glyco-peptides useful for identification of cell adhesion inhibitors

US5795958A · kind A · utility

Assignee

• Glycomed Incorporated · US

Inventors

• Narasinga Rao · Alameda, US
• Morten Meldal · Randers, DK
• Klaus Bock · Kelsterbach, DE
• Ole Hindsgaul · Edmonton, CA

Key dates

• Filing date: Jun 10, 1996
• Grant date: Aug 18, 1998
• Expiry date: Jun 10, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Glycopeptides having the following structure are described: ##STR1## wherein: X.sub.1 is hydrogen, an acetyl group, an acyl group or amino acid; R is .alpha.-L-fucose, .alpha.-D-fucose, .beta.-L-fucose or .beta.-D-fucose, wherein R is O-glucosidically linked to A.sub.1 ; A.sub.1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A.sub.2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A.sub.3 is L or D aspartic acid, glycine or glutamic acid; and X.sub.2 is a hydroxyl, an amine or an amino acid.