Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
US5797887A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 27, 1996 |
| Grant date | Aug 25, 1998 |
| Priority date | — |
| Expiry date | Aug 27, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/926
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a layer affixed to that surface and thus restrict the flow of blood past that surface or to form a blood clot detachable from that surface which when detached could trigger a stroke, heart attack or partial loss of organ function, such as plastic tubing, a balloon or the end of a catheter surgically inserted in a blood vessel or a stent implanted therein, e.g., in conjunction with percutaneous transluminal coronary angioplasty or the interior wall of a length of plastic tubing used to transport the blood of a patient, undergoing hypothermic surgery or dialysis, inhibits such aggregation when that surface is coated with a physiologically acceptable polymer, such as polyvinyl alcohol or polyvinyl chloride, containing dissolved or dispersed therein a nitrosyl-containing organometallic compound, whether ionic salt or chelate, which slowly decomposes at the body temperature and in so doing releases a platelet aggregation-inhibiting amount of nitric oxide during either the post-surgical period when the individual is a high risk candida…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.