Derivatized DTPA complexes pharmaceutical agents containing these compounds, their use, and processes for their production

US5798092A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Heinz Gries · Berlin, DE
• Gabrielle Schumann-Giampieri · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Hubert Vogler · Berlin, DE
• Julius Deutsch · Chicago, US
• Juergen Conrad · Marburg, DE

Key dates

• Filing date: Jun 5, 1995
• Grant date: Aug 25, 1998
• Expiry date: Jun 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general Formula I ##STR1## wherein Z.sup.1 and Z.sup.2 in each case independently mean the residue EQU --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R, wherein PA1 m and n means the numbers 0-20, PA1 k, l, q and r means the numbers 0 and 1, and PA1 R means a hydrogen atom, an optionally OR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl residue, or a CH.sub.2 COOR.sup.1 group with R.sup.1 meaning a hydrogen atom, a C.sub.1 -C.sub.6 -alkyl residue, or a benzyl group, with the proviso that at least two substituents X stand for a metal ion equivalent; that one of the substituents Z.sup.1 and Z.sup.2 stands for a hydrogen and the other is not H; that--if n and l each means the number 0--k and r do not simultaneously mean the number 1; that --(O).sub.r --R is not --OH; and that Z.sup.1 and Z.sup.2 are not --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.2 --COOCH.sub.2 C.sub.6 H.sub.5 or --CH.sub.2 --C.sub.6 H.sub.4 --O--(CH.sub.2).sub.5 --COOCH.sub.2 C.sub.6 H.sub.5, are valuable pharmaceutical agents, e.g., for NMR or X-ray imaging.