Bioresponsive pharmacologically-active polymers and articles made therefrom
US5798115A · kind A · utility
Inventors
Key dates
| Filing date | Feb 13, 1997 |
| Grant date | Aug 25, 1998 |
| Priority date | — |
| Expiry date | Feb 13, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/41
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to pharmacologically-active polymeric compounds; to substrates, such as implantable medical devices formed thereof or coated therewith; and to methods of using said compounds or said substrates for providing pharmacological agents released in response to in vivo activation at a desired location in a mammal. The polymeric material has a backbone comprising a pharmacologically-active fragment covalently linked through at least two functional groups within the backbone, wherein the backbone comprises, preferably, polyamide, polyurethane and/or polyurea linkages with, optionally, polyester, polycarbonate, polyether and/or polyvinyl linkages. The preferred pharmacological compounds are fluoroquinolines, particularly, ciprofloxacin. The pharmacologically-active compounds provide in vivo enhanced long term anti-inflammatory, anti-bacterial, anti-microbial and/or anti-fungal activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.