Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
US5798442A · kind A · utility
12Cited by
4References
3Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 21, 1995 |
| Grant date | Aug 25, 1998 |
| Priority date | — |
| Expiry date | Apr 21, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having the formula I: EQU R.sup.1 COAA.sup.1 AA.sup.2 AA.sup.3 NHY are inhibitors of apopain, an enzyme involved in the process of apoptosis. These compounds are useful as research tools as well as in the treatment of any condition in which reduced apoptosis would be beneficial, including immune deficiency syndromes (including AIDS), type I diabetes, pathogenic infections, cardiovascular and neurological injury, alopecia, aging, Parkinson's disease and Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.