Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics
US5800991A · kind A · utility
4Cited by
4References
15Claims
0Family size
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Key dates
| Filing date | Jul 23, 1996 |
| Grant date | Sep 1, 1998 |
| Priority date | — |
| Expiry date | Jul 23, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.