Production of recombinant factor Xa inhibitor of leech Hirudo medicinalis
US5801017A · kind A · utility
3Cited by
6References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1994 |
| Grant date | Sep 1, 1998 |
| Priority date | — |
| Expiry date | Apr 8, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr.sup.26 -gly.sup.110 where tyr.sup.26 -gly.sup.110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn.sup.72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.