Polymeric contrast agents for medical imaging

US5801228A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Kenneth R. Hollister · Pittsford, US
• Kenneth Edmund Keller · Wayne, US
• Dong Wei · Shanghai, CN
• Xin Peng · Wayne, US
• David L. Ladd · Whitehall, US
• Paul Mark Henrichs · Houston, US
• Robert A. Snow · West Chester, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Sep 1, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides polymeric polychelants containing polymer repeat units of formula L--Ch--L--B! (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R.sub.1 relaxivities.