Arteminolide derivatives and process for the manufacture thereof
US5801254A · kind A · utility
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3Claims
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Key dates
| Filing date | Aug 5, 1997 |
| Grant date | Sep 1, 1998 |
| Priority date | — |
| Expiry date | Aug 5, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Arteminolides obtained from Artemisia sylvatica MAXIMOWICZ and having a core structure of formula (I) or an isomeric structure thereof are effective farnesyl-protein transferase inhibitors as well as angiogenesis suppressors, and, accordingly, they are useful for the treatment of various cancers and angiogenesis-related diseases. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.