Sequestered imaging agents
US5804158A · kind A · utility
2Cited by
10References
19Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 31, 1995 |
| Grant date | Sep 8, 1998 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds useful for high resolution diagnostic imaging incorporate an imaging agent having a chelator that is linked by a metal-cleavable bond to a ligand that has affinity for a site removed from the site of diagnostic interest. Upon labelling, the ligand is cleaved leaving the labelled imaging agent free to localize at the site of diagnostic interest unhindered, while the ligand and any unlabelled imaging agent is sequestered to the removed site. By sequestering unlabelled imaging agent, the labelled imaging agent does not compete to occupy the site of interest, resulting in images of enhanced resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.