Truncated PSPA lacking a functional cell membrane anchor region
US5804193A · kind A · utility
17Cited by
1References
10Claims
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Key dates
| Filing date | Mar 17, 1994 |
| Grant date | Sep 8, 1998 |
| Priority date | — |
| Expiry date | Mar 17, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
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