Lubricious hydrogel surface modification
US5804318A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1995 |
| Grant date | Sep 8, 1998 |
| Priority date | — |
| Expiry date | Oct 26, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31935
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
New and improved lubrifying coatings for reducing the coefficients of friction of surfaces on medical devices include hydrophilic copolymers derived monoethylenically-unsaturated monomers including some monomers having pendant primary amine functionality and some monomers having pendant tertiary amine functionality. The lubricious hydrogel coatings are covalently bondable to epoxy functionalized surfaces on the medical equipment to provide firmly adherent hydrogel coatings that are slippery when wet. Epoxy functionalized surfaces are provided by epoxy functional or epoxy group containing silane coupling agents. The pendant tertiary amine moieties are readily convertible at alkaline pH to quaternary ammonium cations to which anionic anti-thrombogenic agents may be bonded. Three dimensional copolymer matrices may also be provided as coatings on the surfaces by crosslinking the copolymers before or after attachment to the surface being treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.