Microbiological method of making 5-ketogluconate

US5804423A · kind A · utility

Assignees

• Forschungszentrum Jülich GmbH · DE
• RHEIN BIOTECH GMBH · DE

Inventors

• Ralf Klasen · Leverkusen, DE
• Stephanie Bringer-Meyer · Jülich, DE
• Hermann Sahm · Jülich, DE
• Cornelies Petrus Hollenberg · Düsseldorf, DE

Key dates

• Filing date: Jan 31, 1996
• Grant date: Sep 8, 1998
• Expiry date: Jan 31, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/58
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method is disclosed for preparing 5-ketogluconate, which comprises the steps of: PA1 (a) genetically modifying a microorganism capable of microbiologically producing 5-ketogluconate to increase gluconate NADP.sup.+ -5-oxidoreductase gene expression of said microorganism; PA1 (b) culturing said microorganism in a medium to produce 5-ketogluconate; and PA1 (c) recovering 5-ketogluconate from said medium.