fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1996 |
| Grant date | Sep 8, 1998 |
| Priority date | — |
| Expiry date | Jan 19, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention encompasses structures of the formula I: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: G represents ##STR2## where Q is aryl substituents optionally mono or disubstituted with hydroxy or halogen; PA1 T is halogen, hydrogen, hydroxyl, amino or alkoxy having 1-6 carbon atoms; PA1 W is oxygen, nitrogen, sulfur, or optionally substituted methylene; PA1 X is hydrogen, hydroxyl, or alkyl; PA1 Z is an organic or inorganic substituent optionally forming a ring with subtituents on Q; ##STR3## independently represent optionally substituted carbon chains; wherein k, m, and n are independently 0, or an integer of from 1-3 R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and represent organic or inorganic substituents. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.