Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents

US5807535A · kind A · utility

Assignee

• AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION · AU

Inventors

• Suzanne Virginia Smith · Sydney, AU
• Richard M. Lambrecht · West Allis, US
• Peter Schmidt · Straubing, DE
• Fook-Thean Lee · Sydney, AU
• Therese M. Donlevy · Sydney, AU
• Nadine M. Di Bartolo · Sydney, AU

Key dates

• Filing date: Dec 15, 1995
• Grant date: Sep 15, 1998
• Expiry date: Dec 15, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A physiologically acceptable, radiolabelled compound of general formula (I) consisting of a compound of the ##STR1## where k is an integer from 2 to 5 l is an integer from 1 to 5 X and Y are independently selected from phenyl, naphthyl, pyridine or quinoline radical, each having at position 2 one of --OH, --SH, --NH.sub.2 or --COOH and each of X and Y can be optionally substituted by one or more amino, halogen, hydroxy, mercapto, nitro, cyano, thiocyano, alkyl, alkoxy, halogenoalkyl, acyl, acylamino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, pyridoylamino, N-carboxyalkyl-carbamoyl, sulpho, sulphamoyl, mono- or dialkylated or phenylated sulphamoyl which can also carry one or more substituents R', alkylsulphonyl, alkoxysulphonyl, or by an optionally hydroxy-containing phenylsulphonyl or phenoxysulphonyl; where R' is as defined for X and Y; or pharmaceutically acceptable salts thereof.