Collagen-based injectable drug delivery system and its use
US5807581A · kind A · utility
158Cited by
22References
49Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 29, 1995 |
| Grant date | Sep 15, 1998 |
| Priority date | — |
| Expiry date | Sep 29, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2063
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.