Compound FO-1289, process of production with aspergillus and strain

US5807721A · kind A · utility

Assignee

• The Kitasato Institute · JP

Inventors

• Satoshi Omura · Tokyo, JP
• Hiroshi Tomoda · Oshima, JP
• Rokuro Masuma · Tokyo, JP

Key dates

• Filing date: Dec 4, 1995
• Grant date: Sep 15, 1998
• Expiry date: Dec 4, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/913
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A FO-1289 substance of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or acyl. A process for the production thereof comprises culturing the novel microorganism Aspergillus sp. FO-1289 FERM BP-4242 in a nutrient medium, accumulating the FO-1289 substance thus produced in the medium, and isolating the FO-1289 substance therefrom. Particular species of the FO-1289 substance comprise FO-1289A, in which R.sub.1, R.sub.2 and R.sub.3 are acetyl and R.sub.4 is hydrogen; FO-1289B, wherein R.sub.1 is propionyl, R.sub.2 and R.sub.3 are acetyl and R.sub.4 is hydrogen; FO-1289C, wherein R.sub.1 and R.sub.3 are acetyl, R.sub.2 is propionyl and R.sub.4 is hydrogen; and FO-1289D, wherein R.sub.1 and R.sub.2 are acetyl, R.sub.3 is propionyl and R.sub.4 is hydrogen.