Arylbenzoylguanidines

US5807896A · kind A · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Manfred Baumgarth
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Aug 25, 1995
• Grant date: Sep 15, 1998
• Expiry date: Aug 25, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Arylbenzoylguanidines of the formula I ##STR1## in which R.sup.1 R.sup.2, R.sup.3 and Ph have the given meanings herein, and also the physiologically harmless salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.