Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents

US5807899A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rolf Bohlmann · Berlin, DE
• Joseph Heindl · Berlin, DE
• Hermann Kunzer · Hermeskeil, DE
• Yukishige Nishino · Berlin, DE
• Karsten Parczyk · Berlin, DE
• Martin Schneider · Remchingen, DE

Key dates

• Filing date: Jul 5, 1996
• Grant date: Sep 15, 1998
• Expiry date: Jul 5, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention describes the new triphenylethylenes of general formula I ##STR1## in which n means an integer from 1 to 10, PA1 R' means a sulfur-containing organic radical, PA1 R" means a hydrogen atom, an iodine atom or a hydroxy groups, PA1 E means a hydrogen atom, PA1 G means a hydrogen atom or PA1 E and G together mean a methylene bridge. The new compounds have strong antiestrogenic properties and are suitable for the production of pharmaceutical agents, for example for treating breast cancer.