Process for preparing active carbonates of polyalkylene oxides for modification of polypeptides
US5808096A · kind A · utility
161Cited by
16References
14Claims
0Family size
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Key dates
| Filing date | Jan 21, 1997 |
| Grant date | Sep 15, 1998 |
| Priority date | — |
| Expiry date | Jan 21, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.