Preparation of cis-4-O-protected-2-cyclopentenol derivatives
US5808112A · kind A · utility
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13Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 17, 1997 |
| Grant date | Sep 15, 1998 |
| Priority date | — |
| Expiry date | Jun 17, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100.degree. C. to about 20.degree. C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.