Expression of the recombinant tumor necrosis factor binding protein I (TBP-I)

US5811261A · kind A · utility

Assignee

• YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL

Inventors

• David Wallach · Rehovot, IL
• Yaron Nophar · Ramat Gan, IL
• Oliver Kemper · Orlando, US
• Hartmut Engelmann · Munich, DE
• Cord Brakebusch · Braunschweig, DE
• Dan Aderka · Holon, IL

Key dates

• Filing date: Sep 24, 1993
• Grant date: Sep 22, 1998
• Expiry date: Sep 24, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tumor Necrosis Factor Binding Protein I (TBP-I), precursors and analogs thereof, are produced by transfecting eukaryotic cells with an expression vector comprising al DNA molecule encoding the whole human type I TNF receptor or a soluble domain thereof, and culturing the transfected cells, whereby the soluble proteins are secreted into the medium.