Multiply fucosylated dicarboxylic acids possessing antiadhesive properties

US5811405A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Alexander Toepfer · Hofheim, DE
• Gerhard Kretzschmar · Eschborn, DE
• Eckart Bartnik · Hochheim, DE
• Christoph Huls · Wackernheim, DE
• Dirk Seiffge · Hochheim, DE

Key dates

• Filing date: Jan 24, 1997
• Grant date: Sep 22, 1998
• Expiry date: Jan 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H3/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to multiply fucosylated dicarboxylic acid derivatives possessing antiadhesive properties, to a process for preparing them, to their use, and to pharmaceuticals and diagnostic agents which are prepared from these derivatives. These multiply fucosylated dicarboxylic acid derivatives are suitable for preparing pharmaceuticals or diagnostic agents for diseases which are associated with an excessive, selectin receptor-mediated cell adhesion in the tissue which is affected by the disease.