Substituted chromanysulfonyl (thio) ureas, processing for their preparation and pharmaceutical uses thereof

US5811448A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Englert · Hofheim, DE
• Uwe Gerlach · Hattersheim, DE
• Dieter Mania · Königstein, DE
• Wolfgang Linz · Mainz, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Erik Klaus · Kelkheim, DE
• Peter Crause · Offenbach, DE

Key dates

• Filing date: Dec 4, 1996
• Grant date: Sep 22, 1998
• Expiry date: Dec 4, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted chromanylsulfonyl(thio)ureas, processes for their preparation, their use in pharmaceutical preparations, and pharmaceutical preparations comprising them Chromanylsulfonyl(thio)ureas of the formula I ##STR1## are useful pharmaceuticals for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmia. They can be used as antiarrhythmics and are suitable for the prevention of sudden heart death, for the treatment of cardiac insufficiency and also heart failure as a result of the effects of shock.