Monoamine oxidase B inhibitors, processes for their preparation and use thereof

US5811456A · kind A · utility

Assignees

• Laboratoires Mayoly Spindler · FR
• Michel Seman · FR

Inventors

• Michel Seman · Paris, FR
• Suzanne Bernard · Paris, FR
• Rene L. Milcent · Aulnay-sous-Bois, FR
• Catherine Paillat · Chatou, FR

Key dates

• Filing date: Aug 6, 1996
• Grant date: Sep 22, 1998
• Expiry date: Aug 6, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C271/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel monoamine oxidase B inhibitors of formula (I), wherein R.sub.1 .dbd.H, an optionally substituted benzyloxy or phenylethoxy group; p=0-3; R.sub.3 .dbd.H, a CN, OH, CCH group, a C.sub.1 -C.sub.3 alkoxy-carbonyl group, or a C.sub.1 -C.sub.3 alkylated cyanomethyl group; R.sub.2 .dbd.H or a C.sub.1 -C.sub.3 alkyl group; n=0 or 1; if n=0, R.sub.4 is a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group, while if n=1, y=1 and R.sub.4 is a C.sub.1 -C.sub.3 alkyl group, a C.sub.1 -C.sub.3 alkoxy group or a phenyl group. The invention also concerns processes for the preparation of said novel inhibitors and the therapeutic use thereof. ##STR1##