Ortho substituted aromatic compounds useful as antagonists of the pain enhancing effects of E-type prostaglandins
US5811459A · kind A · utility
22Cited by
15References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 4, 1996 |
| Grant date | Sep 22, 1998 |
| Priority date | — |
| Expiry date | Jun 4, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to compounds of the formula (I): ##STR1## wherein A, B and D are various ring systems such as phenyl, R.sup.1 includes carboxy, R.sup.3 is hydrogen or C.sub.1-4 alkyl and Z is a linking group such as --(CH(R.sup.5)).sub.m -- wherein m is 2, 3 or 4, and R.sub.5 includes hydrogen and methyl; and pharmaceutically acceptable salts and in vivo hydrolysable esters or amides thereof, processes for preparing these compounds, pharmaceutical compositions comprising them, and their use in the treatment of pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.