Water soluble fullerenes with antiviral activity

US5811460A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Simon H. Friedman · San Francisco, US
• Raymond F. Schinazi · Decatur, US
• Fred Wudl · Lompoc, US
• Craig L. Hill · Atlanta, US
• Diane L. De Camp · Atlanta, US
• Rintje P. Sijbesma · 's-Hertogenbosch, NL
• George L. Kenyon · San Francisco, US

Key dates

• Filing date: Jan 24, 1994
• Grant date: Sep 22, 1998
• Expiry date: Jan 24, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/904
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A water soluble derivative of buckministerfullerene (C.sub.60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.