Process for the preparation of mono- and bis(phosphocholine) derivatives which have antifungal activity
US5811568A · kind A · utility
4Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 28, 1994 |
| Grant date | Sep 22, 1998 |
| Priority date | — |
| Expiry date | Apr 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be 1,22-bis2-(trimethylammonium)ethylphosphatyl! docosane is disclosed. Also disclosed is a synthetic process for obtaining a novel class of mono- and bis(phosphocholine) derivatives which are useful as antiinfective agents. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.