Transgenic mammal encoding ornithine decarboxylase

US5811634A · kind A · utility

Assignees

• Thomas G. O'Brien · US
• Janet A. Sawicki · US
• Louis Megosh · US
• Dan Rosson · US
• Susan Gilmour · US
• Manfred Blessing · DE

Inventors

• Thomas G. O'Brien · Lititz, US
• Janet Sawicki · Newtown Square, US
• Susan K. Gilmour · Lansdowne, US
• Louis C. Megosh · Upper Darby, US
• Manfred Blessing · Saulheim, DE

Key dates

• Filing date: Sep 12, 1995
• Grant date: Sep 22, 1998
• Expiry date: Sep 12, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

RACTS (J. Invest. Dermatol.) (1990), 94(4):573. Halmekyto et al., "Characterization of a Transgenic Mouse Line Over-Expressing the Human Ornithine Decarboxylase Gene" (1991), Biochem. J. 278:895-989. Halmekyto et al., "Trangenic Mice Aberrantly Expressing Human Ornithine Decarboxylase Gene", (1991) J. Biol. Chem 266(29):19746-19751. Hibshoosh et al., "Effects of Overexpression of Ornithine Decarboxylase (ODC) on Growth Control and Oncogene-Induced Cell Transformation", Oncogene (1991), 6:739-743. Koza et al., "Constitutively Elevated Levels of Ornithine and Polyamines in Mouse Epidermal Papillomas", Carcinogenesis (1991), 12(9):1619-1625. Halmekyto et al., "Enhanced Papilloma Formation in Response to Skin Tumor Promotion in Transgenic Mice Overexpressing the Human Ornithine Decarboxylase Gene", (1992), Biochem. and Biophys. Res. Comm. 187(1):493-497. Kauppinen et al., "Nuclear Magnetic Resonance Spectroscopy Study on Energy Metabolism, Intracellular pH, and Free Mg.sup.2+ Concentration in the Brain of Transgenic Mice Overexpressing Human Ornithine Decarboxylase Gene" (1992) J. Neurochem. 58(3):831-836. Blessing et al., "Transgenic Mice as a Model to Study the Role of TGF-.beta.-Rel…