Time-resolved diffusion tomographic imaging in highly scattering turbid media
US5813988A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 18, 1996 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Mar 18, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0091
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: EQU X.sup.(k+1).spsp.T =Y.sup.T W+X.sup.(k).spsp.T .LAMBDA.!W.sup.T W+.LAMBDA.!.sup.-1 wherein W is a matrix relating output at detector position r.sub.d, at time t, to source at position r.sub.s, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, <nn> to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: EQU .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j =<nn>/<.DELTA.Xj.DELTA.Xj> Here Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.