Sphingosomes for enhanced drug delivery
US5814335A · kind A · utility
79Cited by
3References
12Claims
0Family size
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Key dates
| Filing date | Sep 17, 1997 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Sep 17, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1278
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.