Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
US5814440A · kind A · utility
9Cited by
3References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1997 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Feb 27, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a novel antibody, designated .alpha.EM10, and a hybridoma cell line that produces the .alpha.EM10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation technique utilizing antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.