S-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them
US5814608A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 21, 1997 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Apr 21, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C50/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR.sub.4 wherein R.sub.4 is chosen in the group consisting of CHO, COCH.sub.3, acyl derivative of a carboxylic acid containing up to 6 carbon atoms; PA0 R.sub.1 is chosen in the group consisting of: H, OH, OCH.sub.3 ; PA0 R.sub.2 is chosen in the group consisting of: H, OH, NH.sub.2 PA0 R.sub.3 is chosen in the group consisting of: H, OH, NH.sub.2, residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.