Osteogenic growth oligopeptides and pharmaceutical compositions containing them

US5814610A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Itai Bab · Mazkeret Batya, IL
• Andras Muhlrad · Jerusalem, IL
• Michael Chorev · Sharon, US
• Arie Shteyer · Mevaseret Tsiyon, IL
• Zvi Greenberg · Ramat HaSharon, IL
• Nura Mansur

Key dates

• Filing date: Jan 5, 1996
• Grant date: Sep 29, 1998
• Expiry date: Jan 5, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr-Gly-Phe-His-Gly (SEQ.ID.No.2) and Gly-Phe-Gly-Gly (SEQ.ID.No.3). The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic or fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.