Compounds derived from boronic acid
US5814622A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1997 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Feb 27, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compound of formula (I) ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen or alkyl or alternatively R.sub.1 and R.sub.2 form, with the carbon atom which bears them, cycloalkyl, PA1 R.sub.3 represents hydrogen or alkyl, phenyl or benzyl, PA1 R.sub.4 represents: PA2 optionally substituted amino, optionally substituted amindino, optionally substituted guanidino, optionally substituted isothioureido, optionally substituted iminomethylamino, mercapto substituted with heterocyclic, or heterocyclic, PA1 R.sub.5 and R.sub.6 each represent hydrogen or alkyl, or ##STR2## forms a boronic ester of pinanediol, m represents an integer such that 0.ltoreq.m.ltoreq.6, PA1 n represents an integer such that 1.ltoreq.n.ltoreq.6, PA1 A represents any one of the following groups: PA2 * optionally substituted bicycloalkyl (C.sub.5 -C.sub.10)phenyl, PA2 * or a group of formula: ##STR3## A.sub.1 represents --CO--, --CS--, --SO.sub.2 --, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as trypsin-like serine proteases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.