Benzyl-substituted compounds having dopamine receptor affinity
US5814628A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1996 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Dec 10, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D267/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; PA0 X.sub.1 is selected from CH.sub.2, O, NH, S, C.dbd.O, CH--OH, CH--N(C.sub.1-4 alkyl).sub.2, C.dbd.CHCI, C.dbd.CHCN, N--C.sub.1-4 alkyl, N-acetyl, SO.sub.2 and SO; PA0 X.sub.2 --is selected from N.dbd., CH.sub.2 --, CH.dbd., C(O)--, O--, and S--; PA0 Y is selected from CH and N; PA0 Z is cyano PA0 R.sub.1 represents C.sub.1-4 alkyl; PA0 m is 0, 1, 2 or 3; PA0 n is 0, 1 or 2; PA0 q is 1 or 2; and PA0 D is a 5, 6 or 7-membered, saturated or unsaturated, homo- or heterocyclic ring; and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.