Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
US5814639A · kind A · utility
90Cited by
15References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1993 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Feb 16, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.