Inhibitors of amyloid beta-protein production
US5814646A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 2, 1995 |
| Grant date | Sep 29, 1998 |
| Priority date | — |
| Expiry date | Mar 2, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of protecting a warm-blooded mammal from the progression of Alzheimer's disease, which comprises administering an effective amount of a compound of general formula. ##STR1## in which: R.sup.1 represents an optionally substituted aromatic or heteroaromatic group; PA1 L.sup.1 and L.sup.2 each independently represents a bond or an unbranched (1-4C) alkylene group, which alkylene group may optionally bear a (1-4C) alkyl, phenyl or phenyl (1-2C) alkyl substituent; PA1 one of Y.sup.1 and Y.sup.2 represents NR.sup.3 and the other represents O, S or NR.sup.3, in which R.sup.3 represent hydrogen, hydroxyl, (1-4C) alkoxy, (1-4C) alkyl or di (1-4C) alkylamino; PA1 Z represents O or S; and PA1 R.sup.2 represents (3-8C) cycloalkyl, heterocyclyl, and optionally substituted aromatic or heteroaromatic group, or together with L.sup.2, (1-10C) alkyl; PA1 or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.