Antidote for hirudin and synthetic thrombin inhibitors and method of use

US5817309A · kind A · utility

Assignee

• Max-Planck-Gesellschaft · DE

Inventors

• Gotz Nowak · Erfurt, DE
• Elke Bucha · Erfurt, DE

Key dates

• Filing date: Aug 9, 1996
• Grant date: Oct 6, 1998
• Expiry date: Aug 9, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an antidote for hirudin and synthetic thrombin inhibitors; the antidote contains a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents. The present invention also relates to the application of a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, or a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents as an antidote for hirudin and synthetic thrombin inhibitors or for the preparation of an antidote for hirudin and synthetic thrombin inhibitors.