Genes for the synthesis of pyrrolnitrin

US5817502A · kind A · utility

Assignee

• Novartis Finance Corporation · US

Inventors

• James M. Ligon · Basel, CH
• Dwight Steven Hill · Cary, US
• Stephen Ting Lam · Raleigh, US
• Philip E. Hammer · Cary, US
• Karl-Heinz van Pee · Rabenau, DE
• Sabine Kirner · Puchheim, DE

Key dates

• Filing date: Oct 9, 1996
• Grant date: Oct 6, 1998
• Expiry date: Oct 9, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P17/10
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.