Modified ribozymes

US5817635A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Fritz Eckstein · Göttingen, DE
• Wolfgang Pieken · Boulder, US
• Fritz Benseler · Oettingen, DE
• David B. Olsen · Johnstown, US
• David M. Williams · Cambridge, GB
• Olaf Heindenreich · Göttingen, DE

Key dates

• Filing date: May 4, 1995
• Grant date: Oct 6, 1998
• Expiry date: May 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The claimed invention is drawn to RNA molecules with catalytic activity comprising at least one modified nucleoside having a modifier group replacing the hydroxy group at the 2'-position of the ribose sugar where the modifier group is an halo, amino, mono- or disubstituted amino, or an azido group, and methods of use in vivo.