Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A · kind A · utility
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16References
22Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Oct 6, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, Y.sub.3 and Y.sub.8 are CH, Y.sub.5, Y.sub.7 and Y.sub.9 are each independently nitrogen, PA1 R is a hydrogen, a C.sub.1 -C.sub.7 alkyl acyl or aryl acyl, PA1 Q is NH.sub.2, halogen or hydrogen, PA1 Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.