5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation

US5817677A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Gunter Linz · Mittelbiberach, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Helmut Pieper · Lohr am Main, DE
• Volkhard Austel · Biberach, DE
• Brian Guth · Warthausen, DE
• Johannes Weisenberger · Biberach, DE

Key dates

• Filing date: Oct 18, 1996
• Grant date: Oct 6, 1998
• Expiry date: Oct 18, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5-Membered heterocyclic compounds, of which the following compounds are exemplary: PA0 (a) 4-trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imida zole, PA0 (b) 5-trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperi dyl)-1,3-thiazole, PA0 (c) 5-4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-t hiazole, PA0 (d) 5-trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3, 4-thiadiazole, PA0 (e) 5-4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiaz ole, PA0 (f) 5-trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole, PA0 (g) 5-4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, PA0 (h) 5-trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole, and PA0 (i) 4-trans-4-carboxycyclohexyl!aminocarbonyl!-1-2-(4-piperidyl)ethyl!imida zole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.