Indole derivatives having a 2-phenyl-ethanolamino-substituted lower alkyl group at the 2-or 3-position thereof
US5817689A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 29, 1997 |
| Grant date | Oct 6, 1998 |
| Priority date | — |
| Expiry date | May 29, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An indole derivative of the formula: ##STR1## wherein R.sub.1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower alkylaminosulfonyl, etc., R.sub.2 is hydrogen, halogen, lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, etc., R.sub.3 is hydrogen or lower alkyl, R.sub.4 is halogen or trifluoromethyl, R.sub.5 is lower alkyl, or a salt thereof, these compounds being potent .beta..sub.3 -adrenergic receptor-stimulating agent with excellent adrenoceptor selectivity, and being useful in the prophylaxis or treatment of obesity or diabetes mellitus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.