DR-nm23 and compositions, methods of making and methods of using the same
US5817783A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 20, 1996 |
| Grant date | Oct 6, 1998 |
| Priority date | — |
| Expiry date | Jun 20, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
DR-nm23 protein is disclosed. A nucleotide sequence encoding the same and fragments thereof, recombinant expression vectors that comprise the nucleotide sequence, host cell comprising the recombinant expression vectors and methods of making DR-nm23 protein are disclosed. Oligonucleotide molecules comprising a nucleotide sequence complementary to a portion of the nucleotide sequence that encodes DR-nm23 and methods of using the same to inhibit DR-nm23 expression are disclosed. Isolated antibodies that bind to an epitope on DR-nm23 are disclosed. Methods of tracking the progress on chronic myelogenous leukemia and methods of detecting the onset of blast crisis phase in an individual with chronic myelogenous leukemia are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.