Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent

US5820848A · kind A · utility

Assignee

• The Liposome Company, Inc. · US

Inventors

• Lawrence Boni · Monmouth Junction, US
• Andrew S. Janoff · Yardley, US
• Sharma R. Minchey · Monmouth Junction, US
• Walter Perkins · Ewing Township, US
• Christine E. Swenson · Princeton, US
• Patrick L. Ahl · West Point, US
• Thomas S. Davis · Valhalla, US

Key dates

• Filing date: Sep 30, 1994
• Grant date: Oct 13, 1998
• Expiry date: Sep 30, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2989
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a composition containing a sized liposome comprising a lipid and an induce; the sized liposome has a diameter of at most about 1 micoron and the induces is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.