Cascade polymer complexes, process for their production and pharamceutical agents containing said complexes

US5820849A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE

Key dates

• Filing date: Jul 3, 1996
• Grant date: Oct 13, 1998
• Expiry date: Jul 3, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cascade polymer complexes that contain PA1 a) complexing ligands of general formula I EQU A-{X-Y-(Z-<W-K.sub.W >.sub.Z).sub.y !.sub.x }.sub.a (I), in which PA1 A stands for a nitrogen-containing cascade nucleus of base multiplicity a, PA1 X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, PA1 Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, PA1 K stands for the radical of a complexing agent, PA1 a stands for numbers 2 to 12, PA1 x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different and that for the product of the multiplicities, PA1 16<a.multidot.x.multidot.y.multidot.z.multidot.w<64 holds true, PA1 b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, PA1 c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as PA1 d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.