Recombinant protein production in bovine adenovirus expression vector system
US5820868A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1993 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Dec 9, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10352
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.