Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor
US5820872A · kind A · utility
19Cited by
5References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 30, 1993 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Jul 30, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2005/1098
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include irradiating the tumor to release tumor-derived antigens in vivo, preparing a cellular vaccine including the isolated antigens admixed with a preparation of altered antigen presenting cells and administering the cellular vaccine to the subject. In the preferred embodiments, the antigen presenting cells are leukocytes that have been photochemically altered by subjecting the cells to photopheresis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.